Contribution of Telomere Maintenance-Associated Genes to Telomere Length
نویسندگان
چکیده
منابع مشابه
Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk.
BACKGROUND Telomeres protect chromosomal ends, shorten with cellular division, and signal cellular senescence, but unchecked telomere attrition can lead to telomere dysfunction, upregulation of telomerase, and carcinogenesis. Shorter telomeres in peripheral blood leukocytes (PBL) have been associated with elevated cancer risk. Furthermore, genetic variants in and around the TERT gene have been ...
متن کاملGenetic Variation in Telomere Maintenance Genes, Telomere Length and Breast Cancer Risk
BACKGROUND Telomeres at the ends of eukaryotic chromosomes play a critical role in maintaining the integrity and stability of the genome and participate in the initiation of DNA damage/repair responses. METHODS We performed a case-control study to evaluate the role of three SNPs (TERT-07, TERT-54 and POT1-03) in telomere maintenance genes previously found to be significantly associated with b...
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Genome-wide systematic screens in yeast have uncovered a large gene network (the telomere length maintenance network or TLM), encompassing more than 400 genes, which acts coordinatively to maintain telomere length. Identifying the genes was an important first stage; the next challenge is to decipher their mechanism of action and to organize then into functional groups or pathways. Here we prese...
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In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
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The role of Ku86 at telomeres has been extensively studied in various organisms; however, a role for Ku86 at human telomeres was unknown because Ku86 deletion is lethal for human cells. Here, we used small interference RNA to decrease Ku86 protein levels in human cells. An approximately 50% reduction in the amount of Ku86 protein was achieved 72 hours after transfection with Ku86-specific small...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2010
ISSN: 1059-7794
DOI: 10.1002/humu.21347